I used to work for a company specialising in delivering AAA rated information websites. Accessibility wasn't difficult, it was an attention to detail thing. A lot of our work was done using CMS. We configured the CMS to pick up metadata to make sure as many of the Accessibility rules as possible were automatically adhered to.
Screen readers can struggle with Electron apps. Marketing people seem to hate the idea that switching colours on their website needs to be a thing. High contrast, colour blind friendly switching especially.
The Yoast plugin on the authors page for this site rewards short sentences. This aids the cognitively impaired.
An Accessible website is accessible by all by definition.
Another point to note. Screen readers can be unstable and buggy. Not sure if they are 64bit compatible either.
I struggle with audio on videos. Frustrated with the lack of transcripts. There's a huge body of knowledge that is inaccessible to me