This stored proc has helped me a lot when I needed to restore db, reconfigure replication, and do other database jobs. SQL server KILL command can only act on a single spid. This sp compiles KILL commands in a cursor to kill a group of spids based on database name, login name, host machine name or simply kills all except 'sa' when there are no parameters specified. It has been tested on SQL 7 and 2000.
Disclaimer: Use this stored proc at your own risk as killing processes may be undesirable under certain circumstances. Use it with caution.
When doing bulk data changes it may be beneficial to disable indexes prior to starting the operation. Fortunately, SQL's rich metadata makes this very easy to automate in a robust fashion.