I was in the UK about 5 years ago and drove most of the circumference - London to Dover, Brighton, over to Wales, through the Lake District, up to Edinburgh, down to York, back to London - about 1100 miles in two weeks. I diud find that I needed a break after a couple of hours driving on the "wrong" side of the road from the "wrong" side of the car. After watching my stress driving, my wife refused to drive at all. I have memories of lanes just wide enough for a Ford Focus and the "wide" roads that were 1 1/2 times that width.
I think I did reasonably well; only one driver ever blew a horn at me - in a traffic circle in Wales.
We met some interesting people (the B&B with a Rockola juke box full of 50's 60's rock&roll; Marie, who has a B&B in a 200 year old farmhouse in the Lake District; Lenny, who has a B&B in Edinburgh) and saw some interesting historical sites and some fantastic countrysides. I can understand why the early British settlers wanted to be in Virginia - there are many areas that remind me of places in the UK.
The justification for having the dominant hand for shifting gears is rapidly going away, as only a small percentage of production passenger cars/vans are manual transmission these days. Even some of the larger trucks have automatic transmissions, both rental and commercial - the trash collection trucks typically shift 4 times in the first 200 feet or so. Now the question is which hand should be used for driving and which for the cell phone