Decades ago I bought a 36" D x 72" L x 28" H desk and the matching 18" D x 72"W x 28" H credenza from my father-in-law when his trucking company was going under. I added a 30" wide keyboard drawer to the desk which holds both my keyboard and mouse. I've used this furniture in my home office in whatever house we've moved to ever since. Sometimes as my personal desk when I did my work at an employer's office, and as my work desk when I've had periods of working from home. I started working from home again about 6 month before the pandemic started. I have always had a dedicated home office room or area of a basement.
For at least a decade I've handled my personal tasks (including photo editing) on my personal Dell 17" laptop in my La-Z-Boy rocker recliner with the feet up and facing my TV for handling my personal tasks, often while watching some program or movie in the background.
I never did build a lab at home, but I've been working for a company that is "all in" with Microsoft Azure for the last 5 years, and I can spin up whatever I need to experiment with.
The biggest change I've made over time was the chair. I originally had some low-end chair I probably got from Staples for $79 in the 90's. About 3 years ago, I "upgraded" to a $20 Facebook Marketplace find that was a high-back executive style chair, but the arms were too high and non-adjustable. I dealt with various shoulder ailments ever since. Maybe it was the chair, maybe just my getting old. My physical therapist advised I get a better chair, so several months ago I bought a reconditioned Steelcase Leap chair for $400 (less than 1/3 the cost of a new one) from a local used office furniture business and it has adjustable everything, including the lumbar support. I'm so much more comfortable and it was definitely worth the investment!
I am using an employer-provided low-end ThinkPad (I RDP to an Azure VM for almost everything) on an Amazon Basics stand, flanked by two Dell 27" monitors (both in landscape orientation), and using a wireless keyboard (with backlit keys like my personal Dell laptop) and mouse from the Logitech Master series. I upgraded to those a couple of years ago from the bottom-of-the-line wired ones my employer provided. With a 36" deep desk with a "modesty panel" that reaches almost to the floor, I needed cable extensions to cover the distance, and got tired of yanking my mouse out the back of the keyboard drawer if I moved my feet the wrong way. I have a Jabra stereo on-ear headset with a hard headband, and my next upgrade will likely be to that. I much prefer an over-ear headset with a padded headband.
The desk faces a white-painted concrete block basement wall in my semi-finished basement. I keep the overhead lights off and use a dimmable LED light that I bounce off the wall, mostly to improve my appearance on video calls and soften the contrast of the whole office area. When I need to look at papers I can turn it way up, but mostly I keep it relatively dim - the monitors provide plenty of light for the desk.
I never print anything for work, but I do have an HP monochrome laser all-in-one on my wireless network. I still have a Canon color inkjet, but I only use it once or twice per year. Once my daughter went off to college, the need for color printing almost vanished.
My biggest regret was taking so long to upgrade to a truly professional chair. It cost less than my physical therapy copays over the last few years, and might well have eliminated the need for those.