I live in a small town near the Great Smoky Mountains in North Carolina, and work for a software company here. There are two challenges I've seen here:
1- Finding qualified developers who want to move here (although I can't understand why they wouldn't want to) when you're hiring.
I can give you three good reasons why people like me don't want to go there: (1) the climate is too cold (probably OK for me, but my wife wouldn't survive a North Carolina Appalachian winter); (2) the nearest sea is in storm and tornado country; and (3) I need the internet and the web for social reasons and for buying things that I can't find locally in England or in Spain, let alone in NC.
Maybe a few decades back, when Ann was fitter (and so was I, and we might have taken chances on storms and tornados when visiting the coast) and getting hold of Gaelic books and music on the web wasn't an issue because there was
no web we might have moved there. I was looking for something new and considering the USA seriously at the beginning of 1969 and again six or seven years later - but then there weren't any jobs: North Carolina only employed mathematicians or computer scientists (no-one was called a "developer" way back then) in the area around Chapel Hill and Raleigh, not in the mountain areas. And the pay in most places in the USA didn't look good.
2- Finding reliable internet access for home when you have to support the business off-hours. Most homes here in the mountains are off the beaten path, and your options for internet are limited.
For those of us who use the internet and the web for all sorts of things other than work, that's probably a killer.
Nevertheless, I still love living here; it's laid back, quiet, and simply beautiful.
Mountains about one and a half times as high as the West Highlands of Scotland - but with about the same prominence/tallness, because they start off from quite high, not from sea level as most of ours do (the closest to the sea the Smokies get is several times further from the sea than the farthest you can get in he West Highlands). So I suspect that I would like it.