Nita,

Thank you very much for your help. I found that was my spelling typo on name of profile. dumb me 😉

No use. MSSQLSERVER and SQLSERVERAGENT run under same domain account. Both SQL Mail and SQL Agent Mail use this profile.

I did EXEC xp_stopmail then EXEC xp_startmail. The sp_startmail got

Server: Msg 18025, Level 16, State 1, Line 0

xp_startmail: failed with mail error 0x80040111

Then I restarted SQL server and...