Thanks Eirikur Eiriksson
I will request the teams raise a...

So the issue is still not resolved.

The only entry in the Microsoft.ReportingServices.Portal.WebHost log file that seems to point to an issue is the following

Microsoft.ReportingServices.Portal.WebHost!reportserverwebapp!3!08/15/2018-12:07:23:: e...

Hello,

So we have simplified the environment and everything is now hosted on a single node to remove the need for Kerberos authentication. 

The site loads and everything...

Using Fiddler when I select the link the following results are returned

Result - 301 
Protocol - HTTP
Host - alias.com
URL - /reports/browse
body - 0
Caching -...

Sorry but I do not know how to do that.  Can you please advise what steps I need to take?

I believe it does point to a valid skin file but if I am checking the wrong area please suggest

I see the following entries in the file E:\WebSites\alias.com\\App_Themes\Gloss...