Since it's 2k5 on server 2k3 you're using IIS. Anything to note in either a) your security event log, b) application event log, c) SQL log, or most probably d) your IIS logfiles (%systemroot%\system32\Logfiles\W3SVC#\). Most likely you'll see some 403 (security) errors in your IIS logs relating to the time. They may be able to point you into the correct direction. Perhaps you are filtering by IP in your IIS Settings and those requests are being dropped because they come from somewhere other than your local LAN? Again your IIS logs will tell you what IP you were coming from when you received your 403 error. Check that against your security settings...
-Luke.
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