Absolutely. That's also a good way of doing backups of VLDBs, especially if using native SQL. Allows you to slice it and dice it to meet your business recovery needs. We had a manufacturing environment where we knew 2/3 of our tables were relatively static and truly only needed to be backed up weekly. They were put into their own file group and backed up accordingly. But our inventory tables were constantly being updated and needed nightly backups. As the database grew, this was the best way to ensure we had what we needed. Then we went with a third party tool and it all became moot - full backups of everything nightly. Look up "BACKUP, filegroup backup" in BOL.