Slowly, maintain eye contact, and carry a really big stick...

Oh, you mean how do decide which one's to implement.

I wouldn't recommend that you use that data by itself. I'd combine it with a collection of long running queries and most frequently called queries. You'll need to collect that with a server side trace. Then, unfortunately, there's no easy way to marry the missing index data to specific queries... Unless you do something like I blogged about here. There are some other people that have also posted scripts that do the same thing (several of them better than mine) so you can do a search to track them down.

Once you decide that a query and a missing index match up and you're ready to use the index, test it. The missing index information is based on estimates within the optimizer, and it can be wrong.