beside the "default" (at least before SQL 2016) Trace Flags 1117 / 1118 (Grow all Files in a FileGroup equally / prevent mixted extends) I'm using:
1222 (allows Deadlock monitoring), 2371(Changes the fixed auto update statistics threshold to dynamic auto update statistics threshold. - not necessary on 2016) and Trace Flag 3226 (Function: By default, every successful backup operation adds an entry in the SQL Server error log and in the system event log. If you create very frequent log backups, these success messages accumulate quickly, resulting in huge error logs in which finding other messages is problematic. With this trace flag, you can suppress these log entries. This is useful if you are running frequent log backups and if none of your scripts depend on those entries)