and a simple cross apply example:
with myCTE(val)
AS
(
SELECT 'Heavy rains that fell across the Upper Mississipp' UNION ALL
SELECT 'i River Basin in the summer of 2007 were responsi' UNION ALL
SELECT 'ble for the Federal Emergency Management Agency (' UNION ALL
SELECT 'FEMA) 1771-DR-IL disaster declaration. These sam' UNION ALL
SELECT 'e rains caused significant flooding in southeaste' UNION ALL
SELECT 'rn Minnesota, eastern Iowa, southern Wisconsin an' UNION ALL
SELECT 'd northern Illinois. Large portions of northern ' UNION ALL
SELECT 'Illinois received between 125 and 175 inches of r' UNION ALL
SELECT 'ain during this period, and this, combined '
)
select val,a.val2
FROM MyCTE
CROSS APPLY (SELECT REPLACE(REPLACE(REPLACE(REPLACE(REPLACE(val, 'A', ''), 'E', ''), 'O', ''), 'U', ''), 'I', '') as val2
) a
Lowell