Not for a query that is running, no. You can use the plan handle to recompile a query in cache, but if it's actively running, it will have to complete. Any other calls against the same plan in cache will get a new plan, but that existing execution will have to complete.
"The credit belongs to the man who is actually in the arena, whose face is marred by dust and sweat and blood"
- Theodore Roosevelt
Author of:
SQL Server Execution Plans
SQL Server Query Performance Tuning