The SQL Server binaries are on a disk that you intend to replace?
Uninstall. Reinstall.
Backup/restore all databases (don't forget the system ones), or detach/attach (and backup/restore the system ones that can't be detached)
Gail Shaw
Microsoft Certified Master: SQL Server, MVP, M.Sc (Comp Sci)
SQL In The Wild: Discussions on DB performance with occasional diversions into recoverability