Hi,
Seems to me you suffer the double hop issue; Kerberos not enabled.
To solve this
Option 1:
Enable Kerberos Authentication
see http://download.microsoft.com/download/B/E/1/BE1AABB3-6ED8-4C3C-AF91-448AB733B1AF/SSRSKerberos.docx%5B/url%5D
Less secure and you use a generic account to access the data source
Option 2:
In ReportManager modify the dataSource credentials to:
'Connect using credentials stored securely in the report server'
Optionally set 'Use as Windows credentials when connecting to the data source'
Hopes this helps,
Regards Kees