• Thanks for your feed back.

    I'd done some initial checking before coming here (not in first post - sorry) the SQL box runs fine from either clients within the same domain or different applications. This is the server for several different applications, only one of which is producing problems for a limited number of users. Further investigations have revealed that they are in the same location - so this may well have more of a bearing on the problem.

    I have also asked the users to keep a log of problems (which wasn't being done before) - so I might actually have something to help me find out what is going on in the future.

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