"I should have spent more time at the office" is a quotation you will never see on a tombstone.

When I was working (happily now retired) I took all the leave including flexitime (if you worked more than the contracted hours the additional time accumulated). That way I stopped doing two peoples' jobs. We did work the long shifts, the out of hours stuff and disasters but we didn't end up jibbering in the corner from mental and physical exhaustion.