what type of replication?
What I've had to run to make sure my scripts are starting clean for merge replication are as follows:
'Drop any subscriptions
exec sp_dropmergesubscription @publication = N'<publication>''
'Drop the publication
exec sp_dropmergepublication @publication = N'<publication>'
'Set the DB to not be for replication
exe sp_replicationdboption @dbname= N'<db>' @optname=N'merge publish' @value = 'FALSE'
If you're using trans rep I believe the commands are similar.
Also if you go into EM and right-click the publication you can choose 'generate script' which will give you the option to see the script for creating or droping the publications.
regards,
Chris