Not totaly clear about if you wanted to remove all spaces or just leading?? If you are tataly striping the characters just use a series of nested "REPLACE" statements.

DECLARE @str1 VARCHAR(100), @str2 VARCHAR(100), @str3 VARCHAR(100)

SET @str1 = 'A & B Cleaners'

SET @str2 = 'A and B Cleaners'

SET @str3 = 'Cleaners A & B'

SELECT '*'+@str1+'*', '*'+REPLACE(REPLACE(@str1, ' ', ''), '&', '')+'*'

SELECT '*'+@str2+'*', '*'+REPLACE(REPLACE(@str2, ' ', ''), '&', '')+'*'

SELECT '*'+@str3+'*', '*'+REPLACE(REPLACE(@str3, ' ', ''), '&', '')+'*'

String Result

*A & B Cleaners**ABCleaners*

*A and B Cleaners**AandBCleaners*

*Cleaners A & B**CleanersAB*