Could you be a bit more specific about what you're trying to do and why?
If you mean query execution, there's hints to force specific indexes but no hint to ignore certain indexes. Besides, in most cases the optimiser should be left to chose indexes based on its costing of the queries.
Gail Shaw
Microsoft Certified Master: SQL Server, MVP, M.Sc (Comp Sci)
SQL In The Wild: Discussions on DB performance with occasional diversions into recoverability