I quickly reviewed a bunch of stuff and have some notes, though I won't go into detail as I have limited time:
Review both instances for updating to the most current SQL Server SP, and possibly CU.
Instance 1:
A lot of growth rates are 10% or 1MB (Review and set for each DB/file)
SQLServerCentral_Data file is limited to 10,000.0 MB and it is over 50% of that size, is that limit what you want?
tempDB: Has testing indicated that you actually need 8 data files?
ips_notifications_log size: 0.0MB?
Instance 2:
tempDB: Has testing indicated that you actually need 8 data files?
Simple-Talk DB: Compatibility level: 80 (Is that needed?)
Simple-Talk_Log Size: 12,908.0 (4x the size of the data file?)
apps_excuse DB: Compatibility level: 80 (Is that needed?), change page_verify to CHECKSUM
apps_prettifier DB: Compatibility level: 80 (Is that needed?), change page_verify to CHECKSUM
sqlMonitor22 DB: autogrowth: 1GB, log size: 46GB? (Almost 8x the size of the data file?)