I'm a fan of TextPad[/url], they claim "It can handle file sizes up to the largest contiguous chunk of 32-bit virtual memory.". I've been using it for years, especially since BRIEF went away.
At $27US, it's a heck of a good deal. It has no problems reading files in Hex, which has been useful many times for me. And it supports RegEx in find/replace operations, also very handy.
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[font="Arial"]Knowledge is of two kinds. We know a subject ourselves or we know where we can find information upon it. --Samuel Johnson[/font]