Please can some help me providing solution to the problem.....

Even i have the same problem....its a SQL 2005 instance in 4 node Cluster servers.

Mail is getting queued up and no logs in the mail event log.

Message

1) Exception Information

===================

Exception Type: Microsoft.SqlServer.Management.SqlIMail.Server.Common.BaseException

Message: There was an error on the connection. Reason: A network-related or instance-specific error occurred while establishing a connection to SQL Server. The server was not found or was not accessible. Verify that the instance name is correct and that SQL Server is configured to allow remote connections. (provider: Named Pipes Provider, error: 40 - Could not open a connection to SQL Server), connection parameters: Server Name: MSSQL$W6053_01, Database Name: msdb

Data: System.Collections.ListDictionaryInternal

TargetSite: Void OpenConnection(Microsoft.SqlServer.Management.Common.SqlConnectionInfo)

HelpLink: NULL

Source: DatabaseMailEngine

StackTrace Information

===================

at Microsoft.SqlServer.Management.SqlIMail.Server.DataAccess.ConnectionManager.OpenConnection(SqlConnectionInfo ci)

at Microsoft.SqlServer.Management.SqlIMail.Server.DataAccess.DataAccessAdapter.OpenConnection(String dbServerName, String dbName, String userName, String password)

at Microsoft.SqlServer.Management.SqlIMail.IMailProcess.QueueItemProcesser.ProcessQueueItems(String dbName, String dbServerName, Int32 lifetimeMinimumSec, LogLevel loggingLevel)

2) Exception Information

===================

Exception Type: System.Data.SqlClient.SqlException

Errors: System.Data.SqlClient.SqlErrorCollection

Class: 20

LineNumber: 0

Number: 53

Procedure: NULL

Server:

State: 0

Source: .Net SqlClient Data Provider

ErrorCode: -2146232060

Message: A network-related or instance-specific error occurred while establishing a connection to SQL Server. The server was not found or was not accessible. Verify that the instance name is correct and that SQL Server is configured to allow remote connections. (provider: Named Pipes Provider, error: 40 - Could not open a connection to SQL Server)

Data: System.Collections.ListDictionaryInternal

TargetSite: System.Data.ProviderBase.DbConnectionInternal GetConnection(System.Data.Common.DbConnection)

HelpLink: NULL