I would check the uptime of the server. Lot's of indexes might seem unused shortly after a reboot. I'm usually hesitant to do any index changes like this until business communicated cycles have completed.
Depending on what you are looking at (0 reads vs. just a few reads), I also check if there are any uses in the plan cache.
If the index is under source control...sweet. If not, get it in there (or script it out), I prefer using Red Gate SQL Source Control and Git
I would then disable the index and eventually by some business approved length of time, drop.
I mention these steps here http://www.codepimp.org/2014/02/source-controlling-indexes/
In order to get SQL Source Control to detect the an index being disabled I had to rename it first.
Why is it that people who can't take advice always insist on giving it?
- James Bond, Casino Royale