What's an interview question that has thrown me for a loop?
"I see that you have lots of strong points. Can you give me one of your weaknesses?"
Fortunately, I had a good answer: "I am a perfectionist."
I've used variants of that answer to good use in the past:
"I don't multitask -- I much prefer to seeing jobs through to completion."
"I don't tolerate trivial interruptions from more important work."
"I'm not very good with the rumor mill / gossip game, so I usually leave that to other people."