I am having the problem as well. It seems to happen when trying to access a database object and I get the error twice before successfully accessing the object.
For example, I try to view the Design View of a table in SQL 2005/2008 Management Studio and get the "Unspecified Error" message. On the 3rd attempt, I am able to view the Design View.
Some people are linking Internet Explorer and the "Unspecified Error" together. For what it's worth, I'm using IE8. But error was happening before I upgraded to IE8.
Any solutions to the problem would be much appreciated! I get the "Unspecified Error" 15 to 20 times each day.
Thanks,
Mike