We all use Laptops exclusively here, but 99% of all work is done through RDP or Citrix.

There's very little local data other than purely personal stuff which arguably shouldn't be on a work machine in the first place.

As a DBA, though, I do have a local SQL Server but no local databases apart from my own play stuff. My local SQL Server service isn't even running most of the time to conserve memory.

I just make sure that no credentials for anything are saved locally. It's a bit of a pain to have to type domain/username and password each time (I have 180 servers to look after) but it's really not that much of a chore.