Thank you for your replies. The information was right on.
I created a scratch table in the database (orders_del) that is just being used to hold the order#'s to be deleted. (I do a truncate on the table first thing.)
Then the Execute SQL Command Taks does the delete:
delete FROM dbo.orders WHERE exists
(SELECT * FROM dbo.orders_del AS tmp
WHERE tmp.cono = dbo.orders.cono
AND tmp.orderno = dbo.orders.orderno
AND tmp.ordersuf = dbo.orders.ordersuf)
This reduced the time from 3 hours to 11 minutes!