• doesn't this do it?

    DECLARE @noVowels [varchar](50)

    SET @noVowels = 'Information System'

    SELECT

    REPLACE(

    REPLACE(

    REPLACE(

    REPLACE(

    REPLACE(@noVowels,'A','')

    ,'E','')

    ,'I','')

    ,'O','')

    ,'U','')