As an accidental DBA we're at 113 instances on 3 Production 2008R2 systems and hundreds of databases but fortunately I was smart and automated EVERYTHING when I took this job. Plus it helps that our developers wrote a lot of stored procedures into our databases so all we have to do is schedule a task and call them. Without automation for maintenance (we use LiteSpeed with Spotlight for monitoring because we can also manage the OS at the same time as SQL) I would lose my mind. This does not include test environments and other smaller database products like Progress OpenEdge.