Hi,
After some research my next step is to try
DBCC FREESYSTEMCACHE (‘TokenAndPermUserStore’)
And see if that has the same effect as DBCC FREEPROCCACHE
Right now the tokenandpermstore cache is 791mb/1874000 entries and running ok.
I will see what it is when it next runs slower.
There is a well documented issue with TokenAndPermUserStore which I have so far overlooked as we are on sp2 however some posts suggests it could still be the cause.
Thanks
Simon