First, before I do anything on a new server I stand up a pre-determined utility database for DBA related activities. Maintenance jobs that I run but not limiting to are:
Clearing out aged backups
Creating backups for new databases that get dropped onto my server ( in my case all DB's are mission critical )
Cycle SQL Server Error Logs
Index Defrag
Smart Re-Indexing
Alerting on Extended Blocking
Again, these are my main chunks for maintenance but definitely not limiting what I have listed. You could have more, 50GB is not really that big. Should be able to get a good grasp on it.
Thanks,
Chris