My preferred method is to import the MS Excel file into a SQL table for verification. I usually set all the columns to a wide NVARCHAR value

You can create a stored procedure to insert the data from the verification table into into your live tables as required.

You can also write logic in the SSIS package to do the same.

Here a link to get you started in import data from MS Excel to SQL Server using SSIS. Come back to us if you need more assistance.

Good luck!

http://www.techrepublic.com/blog/datacenter/how-to-import-an-excel-file-into-sql-server-2005-using-integration-services/205