Speaking of 2008 and 2008R2, our organization was just beginning a project to apply the patches that were provided for TLS 1.2. 
1008R2 - KB3045314 OR KB3045316, the difference being either a QFE or a GDR.

I understand that none of these are cumulative updates. Knowing that, is there a way to tell whether 1) the Spectre/Meltdown GDR patch will overwrite the TLS 1.2 capability, and whether our choice of the QFE or GDR (for TLS 1.2) will make a difference?

Thanks to all for sharing your expertise.
- Mike