However, even 'more secure' operating systems such as Linux have exploitable vulnerabilities. We are engaged in a constant evolutionary 'predator/prey' race, in which there is no finish line.
I disagree. And Linux isn't more secure than Windows. (OpenBSD might be...)
I don't think commercial software has tried. The current infrastructure is built on the sand of mutual trust/ease of use, not security. There's a ton of easy fruit for the black hat to pick up.